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- 1-January 3, 1992
- 2Curtis Stigers (host); Crosby, Stills & Nash; Eric ClaptonJanuary 10, 1992
- 3Dr. John (host), Michael McDonald, Boz Scaggs, Donald FagenJanuary 17, 1992
- 4Elle McPherson (host), INXS, Rat KatJanuary 31, 1992
- 5Lou Reed, Lenny Kravitz, Smashing PumpkinsFebruary 7, 1992
- 6David Crosby (host), Genesis, Mary's Danish, Phil CollinsFebruary 14, 1992
- 7John Prine (host), Van Morrison, Merchant of Venus, John MellencampFebruary 21, 1992
- 8Robbie Robertson (host), U2, Sealhenry Samuel, Live, Teenage FanclubMarch 6, 1992
- 9Johnny Depp (host), Tom Petty and the Heartbreakers (part 1)March 13, 1992
- 10Johnny Depp (host), Tom Petty and the Heartbreakers (part 2)March 20, 1992
- 11JamesMarch 27, 1992
- 12Marc Cohn (host), Sting, John Prine, Ocean BlueApril 3, 1992
- 13Al DiMeola (host); Yes; Apostles; Emerson, Lake & PalmerApril 10, 1992
- 14Johnny Lydon (host), Nirvana, Red Hot Chili Peppers, Ned's Atomic DustbinApril 17, 1992
- 15Arc AngelsApril 24, 1992
- 16Ringo Starr (host), MorrisseyMay 1, 1992
- 17Kenny Loggins (host), Enya, Sarah McLachlanMay 8, 1992
- 18Beastie Boys (hosts), Ugly Kid Joe, Spinal Tap, Steve MillerMay 22, 1992
- 19John Waite (host); Emerson, Lake & Palmer; Bangalore ChoirMay 29, 1992
- 20Fiona (host), Annie Lennox, Guns n' Roses, Poi Dog PonderingJune 5, 1992
- 21Carlos Santana (host), Blues Traveler, Julian Lennon, Tori AmosJune 19, 1992
- 22Joe Mantegna (host), Blues TravelerJune 26, 1992
- 23Joe Mantegna (host), FionaJuly 3, 1992
- 24-July 10, 1992
- 25Damn Yankees, Mr. Big, Concrete BlondeJuly 31, 1992
- 26k.d. lang (host), Tracy Chapman, Simply Red, CrackerAugust 7, 1992
- 27Glenn Frey (host), Santana, The Soup DragonsAugust 14, 1992
- 28Leon Russell (host); Tin Machine; Emerson, Lake & Palmer; Shakespear's SisterAugust 21, 1992
- 29Sarah Jessica Parker (host), Lindsey Buckingham, Evangeline, Jimmy Buffett, Willie NelsonAugust 28, 1992
- 30Kenny G (host)September 4, 1992
- 31Allman Brothers Band (host), Dan FogelbergSeptember 11, 1992
- 32The Cure, The Lovemongers, LemonheadsSeptember 18, 1992
- 33David Sanbord (host), Sinead O'Connor, INXS,October 9, 1992
- 34Angus Young (host), The Black Crowes, Metallica, DanzigOctober 16, 1992
- 35Jeffrey Osbourne (host), James Brown, Richie Sambora, Céline Dion, Kenny G, RTZOctober 23, 1992
- 36Downtown Julie Brown (host), Right Said Fred, Kris Kross, P.M. Dawn, Color Me Badd, Marky Mark, CeCe Peniston, Vanessa Williams, Chaka Khan, Michael McDonaldOctober 30, 1992
- 37Robert Cray (host), Bonnie Raitt, Tom CochraneNovember 6, 1992
- 38Henry Rollins (host); Poison; B-52's; L7; Sonic Youth; Mudhoney, Life, Sex & DeathNovember 13, 1992
- 39Ben Stiller (host), Beastie Boys, Nirvana, Smashing Pumpkins, Ride, EMF, Blind MelonNovember 20, 1992
- 40Willie Nelson (host), John MellencampNovember 27, 1992
- 41Kim Wayans (host), Whitney Houston, Darlene Love & Little Steven, Exposé, Kenny G, Annie Lennox, Curtis Steigers, The Jeff Healey BandDecember 11, 1992
- 42Prince and the NPG (part 1)December 18, 1992
- 43Prince and the NPG (part 2)December 19, 1992