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- 1Malcolm-Jamal Warner (host), En Vogue, Arrested DevelopmentJanuary 1, 1993
- 2EugeniusJanuary 29, 1993
- 3Charlie Sexton (host)February 5, 1993
- 4BeBe & CeCe Winans (Hosts), Charlie Moore, James Brown, CeCe PennistonFebruary 12, 1993
- 5Neneh Cherry & B.P. Fallon (hosts), Robert Cray, PJ HarveyFebruary 19, 1993
- 6Johnny Depp (host), Soul AsylumFebruary 26, 1993
- 7Leonard Cohen (host), Mick JaggerMarch 5, 1993
- 8Brian May (host), Paul McCartney, Guns n' RosesMarch 12, 1993
- 9Hunter S. Thompson (host)March 19, 1993
- 10Tom Arnold (host), The The, Fleetwood MacMarch 26, 1993
- 11Chaka Khan (host), Bobby Brown (part 1)April 2, 1993
- 12Chaka Khan (host), Bobby Brown (part 2)April 9, 1993
- 13Jamie Foxx (host), Eddie Murphy, Dina Carroll, Mary J. BligeApril 16, 1993
- 14Richard Belzer (host), The Wallflowers, Bon Jovi, Coverdale-PageMay 7, 1993
- 15Aimee Mann (host)May 14, 1993
- 16Natalie Merchant (host), GumballMay 21, 1993
- 17Boy George (host), David Bowie, Depeche Mode, Dinosaur Jr.May 28, 1993
- 18Mike Edwards (host), Sonic Youth, L7June 4, 1993
- 19Elvis Costello, BellyJune 11, 1993
- 20Paul Rodgers (host), Van Halen, The JayhawksJune 18, 1993
- 21Joey Ramone (host), The Ramones, TelevisionJune 25, 1993
- 22Aaron Neville (host), Sting, Terence Trent D'Arby, Tasmin ArcherJuly 2, 1993
- 23Black 47 (host), U2July 9, 1993
- 24Gary Cherone, George Michael, Lisa StansfieldJuly 16, 1993
- 25Mick Jones and Lou Gramm (hosts), Robert Plant, Stone Temple PilotsJuly 23, 1993
- 26SWV (host)July 30, 1993
- 27Lisa Germano (host), Elton John, Glenn FreyAugust 6, 1993
- 28Maria McKee (host), Pete TownshendAugust 13, 1993
- 29Paul Shaffer (host)August 20, 1993
- 30The Hooters (host), Chris Isaak, CrackerAugust 27, 1993
- 31Mike Love (host), The Beach Boys, The DevlinsSeptember 3, 1993
- 32Michael McDonald (host), Billy Joel, Marc CohnSeptember 10, 1993
- 33Bruce Hornsby (host), The Grateful Dead, Hothouse FlowersSeptember 17, 1993
- 34Debbie Harry (host), Billy IdolSeptember 24, 1993
- 35Billy Dean (host), James Taylor, Patty Smyth, Shawn ColvinOctober 1, 1993
- 36Juliana Hatfield (host), The Lemonheads, Butthole SurfersOctober 8, 1993
- 37Tommy Tallarico (host), Peter Gabriel, PM Dawn, Ziggy Marley, Stereo MCs, Inner CircleOctober 15, 1993
- 38Mavis Staples (host); Earth, Wind & Fire; Natalie Cole; Oleta AdamsOctober 22, 1993
- 39Bell Biv De Voe and Johnny Gill (hosts), SilkOctober 29, 1993
- 40Chastity Bono and Chance of Ceremony (hosts)November 5, 1993
- 41Matthew Sweet (host)November 12, 1993
- 42Richie Havens (host)November 19, 1993
- 43Ric Ocasek (host), U2November 26, 1993
- 44Rickie Lee Jones (host), UB40, Debbie Harry, RadioheadDecember 3, 1993
- 45Robert Smith (host), The Cure, Black HappyDecember 10, 1993
- 46Boyz II Men (hosts); Harry Connick, Jr.; Gloria Estefan; Aaron NevilleDecember 17, 1993