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- 12015 Kills Montage!!!January 1, 2016
- 2Honeydew and Honeydon't!January 8, 2016
- 3Donald Trunk (Trump Spoof)January 15, 2016
- 4Blizzard of OZ (Wizard of OZ parody)January 22, 2016
- 5Red Shirt SpecialJanuary 29, 2016
- 6Skydiving!February 5, 2016
- 7Return of Passion!February 12, 2016
- 8Ask Orange #20 DELETING YOUTUBE!!!February 19, 2016
- 9Mystic 8-BallFebruary 26, 2016
- 10Spam MailMarch 4, 2016
- 11Fart Club!March 11, 2016
- 12Apple Keynote AddressMarch 18, 2016
- 13Butt Wipe!March 25, 2016
- 14Marshmallow's Gender Revealed!!! (5 MILLION Subscriber Special)April 1, 2016
- 15Ask Orange #21 THE FART AWAKENS!"April 8, 2016
- 16Fruits Convince Little Apple of Zombie Apocalypse (Brothers Convince Sister SPOOF)April 15, 2016
- 17Robot Power!April 22, 2016
- 18Crop Circle Conspiracy!April 29, 2016
- 19Kitchen ImprovementMay 6, 2016
- 20BaconMay 13, 2016
- 21Dragon Fruit ZMay 20, 2016
- 2230 Minutes or LessMay 27, 2016
- 23Annoying Orange vs Sub Zero (Mortal Kombat)June 3, 2016
- 24NASCAR Pit Crew Part Deux!June 10, 2016
- 25Ask Orange #22 MARSHMALLOW'S GENDER DETECTIONJune 17, 2016
- 26Lick a Toad!June 24, 2016
- 27The Amazing Wonderbread!July 1, 2016
- 28Boyz N BerryJuly 8, 2016
- 29Annoying Orange vs Ms. Pac-ManJuly 15, 2016
- 30Ask Orange #23 TNT BUTTJuly 22, 2016
- 31Slippery SoapJuly 29, 2016
- 32FROYOLOAugust 5, 2016
- 33Allergic to PeanutsAugust 12, 2016
- 34Drone RaceAugust 19, 2016
- 35Ask Orange #24 Orange & Pear Have a BabyAugust 26, 2016
- 36Wiggle Jiggle!September 2, 2016
- 37Operation Jumbo DropSeptember 9, 2016
- 38The Land Beyond the KitchenSeptember 16, 2016
- 39Ask Orange #25 Rabid Squirrel Attack!September 23, 2016
- 40ASMRSeptember 30, 2016
- 41Sandwitch!October 7, 2016
- 42Ghoulash!October 14, 2016
- 43Scream for Ice CreamOctober 21, 2016
- 44Ask Orange #26 Pear-y Potter!October 28, 2016
- 45Astronaut Ice Cream!November 4, 2016
- 46Man-Bat!November 11, 2016
- 47Gobble! Gobble!November 18, 2016
- 48Ask Orange #27 Death Star Butt!November 25, 2016
- 49Elf on the ShelfDecember 2, 2016
- 50It's a Wonderful Knife!December 9, 2016
- 51Ask Orange #28 Christmas GOOP!December 16, 2016
- 52Snow CannonDecember 23, 2016
- 532016 KILLS videoDecember 30, 2016